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Smiles: CC(C)S(=O)(=O)C1=CC=CC=C1NC1C=C(NC2=CC=C(C=C2OC)N2CCC(O)CC2)N=C2NC=CC=12
Chemical Name: 2-amino-3-(2
Iadademstat reduces AML tumor growth in mice and rat xenografts and increases survival time in a disseminated model of T-ALL
this agent is highly polyglutamylated and competes for the folate binding site of DHFR
LY 2389575 hydrochloride 17454 Smiles: CC(C)S(=O)(=O)C1=CC=CC=C1NC1C=C(NC2=CC=C(C=C2OC)N2CCC(O)CC2)N=C2NC=CC=12LY2389575 is described here instead of LY2389575 hydrochloride. LY2389575 is a selective negative allosteric modulator (NAM) of metabotropic glutamate receptor 3 (mGlu3) with an IC50 value of 4. 2 M . The metabotropic glutamate receptors (mGlus) are members of the GPCR family C. They are characterized by a large extracellular amino terminal domain for binding agonist. Eight mGlus had been found and were assigned to three groups based on their
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