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9]octacos-18-ene2
InChi: InChI=1S/C21H26ClN5O2/c1-13-10-17(28)19-18(13)20(25-12-24-19)26-6-8-27(9-7-26)21(29)16(11-23)14-2-4-15(22)5-3-14/h2-5
Solubility: DMSO : ≥ 130 mg/mL (134
Smiles: COC1C=C(C=C(OC)C=1OC)NC1=NC(NC2=CC=C3OC(C)(C)C(=O)NC3=N2)=C(F)C=N1
PROTAC BRD4 Degrader-11 5-2 9]octacos-18-ene2PROTAC BRD4 Degrader 11 (compound 9a) is a PROTAC connected by ligands for von Hippel Lindau and BRD4. PROTAC BRD4 Degrader 11 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0. 23 nM and 0. 38 nM, respectively. Product information Molecular Weight: 1292. 56 Formula: C61H75F2N9O12S4 Chemical Name: (2S,4R) 1 [(2S) 2 (11 {[8 (3,5 difluoropyridin 2 yl) 4 (methanesulfonylmethyl) 15
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