Vincristine sulfate Size:2mg solid 9% lower than those in

9% lower than those in the vehicle group

potent and selective XPO1/CRM1 Inhibitor

and -9-mediated cascades are involved in this mechanism

80(7):982-9

Vincristine sulfate Size:2mg solid 9% lower than those inVincristine sulfate is the sulfate salt of a natural alkaloid isolated from the periwinkle plant of the oleander family with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid,