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25-fold greater sensitivity observed for cells with VHL deficiency compared to wild-type (VHL+)
26)27/h3-5
including AKT
Rossignol JF
Emodin noprol 25-fold greater sensitivity observed forEmodin (from Rheum emodi, a Himalayan rhubarb) is a purgative resin, 6 methyl 1,3,8 trihydroxyanthraquinone, from rhubarb, buckthorn and Japanese knotweed (Fallopia japonica syn. Polygonum cuspidatum). Emodin is being studied as a potential agent that could reduce the impact of type 2 diabetes. It is a potent selective inhibitor of the enzyme 11 HSD1. In studies in obese mice, emodin limits the effect of glucocorticoids and may therefore ameliorate
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