Pemafibrate 18971 Smiles: C[C@@]12C[C@@H](CC([C@H]1CC[C@@]13C[C@@H](CC[C@@H]21)C(=C)[C@@H]3O)C(O)=O)O[C@@H]1O[C@H](CO)[C@@H](OS(=O)(=O)O[K])[C@H](OS(=O)(=O)O[K])[C@H]1OC(=O)CC(C)C

Smiles: C[C@@]12C[C@@H](CC([C@H]1CC[C@@]13C[C@@H](CC[C@@H]21)C(=C)[C@@H]3O)C(O)=O)O[C@@H]1O[C@H](CO)[C@@H](OS(=O)(=O)O[K])[C@H](OS(=O)(=O)O[K])[C@H]1OC(=O)CC(C)C

InChiKey: XCYAYLWZCRGKDS-WLHGVMLRSA-N

Tyrphostin AG-18

InChi: InChI=1S/C18H26N2O4/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14/h5-9

Pemafibrate 18971 Smiles: C[C@@]12C[C@@H](CC([C@H]1CC[C@@]13C[C@@H](CC[C@@H]21)C(=C)[C@@H]3O)C(O)=O)O[C@@H]1O[C@H](CO)[C@@H](OS(=O)(=O)O[K])[C@H](OS(=O)(=O)O[K])[C@H]1OC(=O)CC(C)CPemafibrate is a potent PPAR agonist, with EC50s of 1 nM, 1. 10 uM and 1. 58 uM for h PPAR, h PPAR and h PPAR, respectively, and possesses lipid lowering effect. Pemafibrate is a potent PPAR agonist, with EC50s of 1 nM, 1. 10 uM and 1. 58 uM for h PPAR, h PPAR and h PPAR, respectively. Pemafibrate is more than 1000 fold selective towards PPAR than PPAR and PPAR. Pemafibrate (3 mg kg, p. o.) increases plasma h apoA I in human apoA I (h apoA I)