PYR-41 - Ubiquitin-activating Enzyme E1 Inhibitor. CAS# 418805-02-4 Catalog No.:M60201-10S Pro-rich peptide and octaargine derivatives

Pro-rich peptide and octaargine derivatives

but not mTORC2

and then conjugated to the Adenovirus vector containing luciferase gene as adenovirus vector carrier

6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide

PYR-41 - Ubiquitin-activating Enzyme E1 Inhibitor. CAS# 418805-02-4 Catalog No.:M60201-10S Pro-rich peptide and octaargine derivativesPYR 41, CAS No. 418805 02 4, is a ubiquitin activating enzyme inhibitor (UBE1 inhibitor). PYR 41 blocks ubiquitination reactions but paradoxically leads to the accumulation of high MW ubiquitinated proteins. PYR 41 also mediated cross linking of specific protein kinases (Bcr Abl, Jak2) to inhibit their signaling activity. PYR 41 has demonstrated anti tumor activity in animal studies, partially selective protein cross linking may represent an alternate