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5-HT1D receptor antagonist — Ki = 54 nM
Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands
InChi: InChI=1S/C28H26ClF2N3OS/c1-32-20-5-7-21(8-6-20)34(16-17-3-2-4-19(15-17)18-11-13-33-14-12-18)28(35)27-25(29)24-22(30)9-10-23(31)26(24)36-27/h2-4
It has improved PK properties relative to UNC0638 and displayed modest brain penetration in vivo
Erythromycin estolate t III 5-HT1D receptor antagonist — KiErythromycin estolate, erythromycin derivative, is a macrolide antibiotic used in the treatment of a wide variety of bacterial infections. Erythromycin estolate causes several cases of liver injury which mostly include cholestatic hepatitis. Erythromycin estolate toxicity is related to its inhibitory effect on bile acid transport. Product information CAS Number: 3521 62 8 Molecular Weight: 1056. 39 Formula: C52H97NO18S Chemical Name: (2S,3R,4S,6R) 4
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