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VX-745 blocks TNFα production in LPS-stimulated HWB in vitro (IC50 = 177 nM)
151(242)209-119(86-100-90-181-92-193-100)142(233)212-126(95(6)7)147(238)204-112(58-29-41-73-187-156(173)174)135(226)201-114(59-30-42-74-188-157(175)176)139(230)211-127(96(8)9)148(239)207-118(84-98-88-191-103-49-20-18-47-101(98)103)141(232)195-105(129(166)220)51-26-38-70-184-153(167)168)64-32-16-14-15-17-33-65-161(12
Formula: C28H33N5O3
48 hours in HCT116 and SW480 cells) affects the enzyme activity of HDAC and observed that PCA treatment resulted in inhibition of HDAC activity in dose-dependent manner
Methyltetrazine-PEG5-alkyne inhibitors 1 hydrochloride VX-745 blocks TNFα production inMethyltetrazine PEG5 alkyne is a PEG based PROTAC linker that can be used in the synthesis of PROTACs. Product information CAS Number: 1802907 97 6 Molecular Weight: 402. 44 Formula: C20H26N4O5 Chemical Name: 3 methyl 6 [4 (3,6,9,12 tetraoxapentadec 14 yn 1 yloxy)phenyl] 1,2,4,5 tetrazine Smiles: CC1N=NC(=NN=1)C1C=CC(=CC=1)OCCOCCOCCOCCOCC#C InChiKey: OAKPIEOTVXLRCN UHFFFAOYSA N InChi: InChI=1S C20H26N4O5 c1 3 8 25 9 10 26 11 12 27 13 14 28 15 16 29 19
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