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InChiKey: KINMYBBFQRSVLL-UHFFFAOYSA-N
11(11):2499-507
Smiles: CCC1C=CC(C=C2SC(=S)NC2=O)=CC=1
and increased mouse splenic-pLck-pY394 and -IFN-gamma(+) cells in vivo
Crizotinib Hydrochloride - CAS# 1415560-69-8 Size:Solid 2 mg InChiKey: KINMYBBFQRSVLL-UHFFFAOYSA-NCrizotinib (PF 02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c Met and nucleophosmin (NPM) anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell based assays, respectively. Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0. 025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines. Product information CAS Number: 1415560 69 8
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