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the activity of CZ415 against the human cardiac ion channel hERG is assessed in a whole-cell patch-clamp assay in HEK293 cells resulting in an IC50 of 48 μM
β-alanine significantly increases malignant cell sensitivity to doxorubicin
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CAS Number: 229305-39-9
Samuraciclib hydrochloride rofen piconol the activity of CZ415 againstSamuraciclib hydrochloride (CT7001 hydrochloride) is a potent, selective, ATP competitive and orally active CDK7 inhibitor, with an IC50 of 41 nM. Samuraciclib hydrochloride displays 45 , 15 , 230 and 30 fold selectivity over CDK1, CDK2 (IC50 of 578 nM), CDK5 and CDK9, respectively. Samuraciclib hydrochloride inhibits the growth of breast cancer cell lines with GI50 values between 0. 2 0. 3 M. Samuraciclib hydrochloride has anti tumor effects. Product