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72(1):210-9
Smiles: CC(C)(O)C1=CC2=NC(=NC(=C2S1)N1CCOCC1)C1C=NC(N)=NC=1
Ibrutinib is a Btk inhibitor (IC50: 0
The inhibition rate of tumor volume in SKLB-610-treated groups is 70
Adagrasib Catalog No.:M12926-2 72(1):210-9Adagrasib (MRTX849) is a potent, selective, and covalent KRASG12C inhibitor that exhibits favorable drug like properties, selectively modifies mutant cysteine 12 in GDP bound KRASG12C and inhibits KRAS dependent signaling. Product information CAS Number: 2326521 71 3 Molecular Weight: 604. 12 Formula: C32H35ClFN7O2 Synonym: MRTX849 Chemical Name: 2 ((S) 4 (7 (8 chloronaphthalen 1 yl) 2 (((S) 1 methylpyrrolidin 2 yl)methoxy) 5, 6, 7, 8