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Macrostrain is the visible stretch that occurs when negative pressure contracts the foam: Draws wound edges together Provides direct and complete wound bed contact Evenly distributes negative pressure Removes exudate and infectious materials Microstrain is the microdeformation at the cellular level, which leads to cell stretch: Reduces edema Promotes perfusion Promotes granulation tissue formation by facilitating call migration and proliferation Articles A randomised study of NPWT closure versus alginate dressings in peri-vascular groin infections: quality of life, pain and cost

They are also challenging to keep in place and can come loose

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