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10(12):1255-66
and CYP1A2 at 1 µM
InChi: InChI=1S/C9H10F2N2O5/c10-5-6(16)9(11
Inhibition of HDAC activity by ITF2357 ameliorates joint inflammation and prevents cartilage and bone destruction in experimental arthritis
2-chloro-3-Deazaadenosine eimide 10(12):1255-662 chloro 3 Deazaadenosine, a stable analog of adenosine, is an agonist for adenosine receptors . Adenosine receptors are members of G protein coupled receptors (GPCRs). Extracellular adenosine acts as a local modulator with a generally cytoprotective function in the body. Extracellular adenosine has been implicated in increasing the ratio of oxygen supply to demand, protecting against ischaemic damage by cell conditioning, triggering anti inflammatory