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Molecular Weight: 491
InChiKey: GMYLVKUGJMYTFB-UHFFFAOYSA-N
ABT-888 dihydrochloride increases apoptosis and autophagy in H460 cells when combination with radiation
Kulkarni A
CC-115 - CAS# 1228013-15-7 Catalog No.:M6483-10 Molecular Weight: 491CC 115, CAS No. 1228013 15 7, is a dual inhibitor of DNA dependent protein kinase (DNA PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. CC 115 binds to and inhibits the activity of DNA PK and both raptor mTOR (TOR complex 1 or TORC1) and rictor mTOR (TOR complex 2 or TORC2), which may lead to a reduction in cellular proliferation of cancer cells expressing DNA PK and TOR. DNA PK, a serine threonine kinase and a