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InChiKey: DJWYOLJPSHDSAL-ROUUACIJSA-N
Formula: C26H37N5O5
Addition of the 12/15-LO inhibitor
TBHQ (tert-Butylhydroquinone) is also an ERK activator
CDK12-IN-2 andicarboxylic acid InChiKey: DJWYOLJPSHDSAL-ROUUACIJSA-NCDK12 IN 2 is a potent, selective and nanomolar CDK12 inhibitor (IC50=52 nM) with good physicochemical properties. CDK12 IN 2 is also a strong CDK13 inhibitor due to CDK13 is the closest homologue of CDK12. CDK12 IN 2 shows excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7. CDK12 IN 2 inhibits the phosphorylation of Ser2 in the C terminal domain of RNA polymerase II. CDK12 IN 2 can be used an excellent chemical probe for functional studies
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