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Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology
Molecular Weight: 437
GW 791343 also reduces maximal responses to ATP and BzATP in sucrose buffer
Molecular Weight: 572
PHA-793887 )hydrazono)butane-1 3-dione Targeting myocardial remodelling to developPHA 793887 is an inhibitor of multiple cyclin dependent kinases (CDK) with activity against CDK2, CDK1 and CDK4. PHA 793887 was cytotoxic for leukemic cell lines in vitro, with IC(50) ranging from 0. 3 to 7 microM. In colony assays PHA 793887 showed very high activity against leukemia cell lines, with an IC(50) <0. 1 microM indicating that it has efficient and prolonged antiproliferative activity. PHA 793887 induced cell cycle arrest, inhibited Rb and
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