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Aleuritic acid derivates have Anti-HIV activity
Bencherif M
García-Martínez JM
XL388 inhibited cellular phosphorylation of mTOR complex 1 (p-p70S6K
GDC-0152 ridol (Alvocidib) Aleuritic acid derivates have Anti-HIVGDC 0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC 0152 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome linked IAP (XIAP) and the cellular IAPs 1 and 2, which may inhibit their activities and promote the induction of apoptosis through apoptotic signaling pathways. IAPs are
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