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Dp44mT shows the greatest antitumor efficacy with an IC50 that ranged from 0
CC1N(CC2=CN=CC=N2)C2=C(C(=O)C3=CC=CC=C3C2=O)[N+]=1CCOC
Chemical Name: 4-(2-aminoethoxy)-N2
Formula: C22H18N4O2S3
BG45 - HDAC3 Inhibitor. CAS# 926259-99-6 Catalog No.:M60266-10S Dp44mT shows the greatest antitumorBG45, CAS No. 926259 99 6, is a potent, selective and cell permeable HDAC3 inhibitor. It inhibits HDAC3 with IC50 of 289 nM. It has IC50 of 2. 0 M, 2. 2 M and >20 M for HDAC1, HDAC2, and HDAC6 in cell free assays, respectively. BG45 triggers significant MM cell growth inhibition via apoptosis, evidenced by caspase and poly (ADP ribose) polymerase cleavage. BG45 alone and in combination with bortezomib triggers significant tumor growth inhibition in
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