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SAR-20347 inhibits TYK2- and JAK1-mediated IL-12 and IFN-α signaling
The retention or efflux of phthalanilide (NSC 60339)-lipid complexes by sensitive or resistant murine tumor cells and Escherichia coli B
at a dose of 50 mg/kg
Cottiglia F
Losmapimod - CAS# 585543-15-3 Size:Solid 2 mg SAR-20347 inhibits TYK2- and JAK1-mediatedLosmapimod, also know as GW856553 or GW856553X or GSK AHAB, is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen activated protein kinases. p38 mitogen activated protein kinases are mediators of inflammation. A Phase II human clinical trial for the treatment of COPD (chronic obstructive pulmonary disease) is underway. Inhibiting these enzymes has been shown to produce antidepressant and
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