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4-trimethylcyclohex-2-en-1-one
Nanchangmycin A
PubMed PMID: 27306340
InChiKey: KKVZKYOBQGDKIB-UHFFFAOYSA-N
(R)-CR8 trihydrochloride Size:10mg solid 4-trimethylcyclohex-2-en-1-one(R) CR8 (CR8) trihydrochloride, a second generation analog of Roscovitine, is a potent CDK1 2 5 7 9 inhibitor. (R) CR8 trihydrochloride inhibits CDK1 cyclin B (IC50=0. 09 M), CDK2 cyclin A (0. 072 M), CDK2 cyclin E (0. 041 M), CDK5 p25 (0. 11 M), CDK7 cyclin H (1. 1 M), CDK9 cyclin T (0. 18 M) and CK1 (0. 4 M). (R) CR8 trihydrochloride induces apoptosis and has neuroprotective effect. (R) CR8 trihydrochloride acts as a molecular glue degrader that
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