Volasertib trihydrochloride - CAS# 946161-17-7 bradine Hydrochloride InChi: InChI=1S/C20H27NO3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21-24)11-12-20(17

InChi: InChI=1S/C20H27NO3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21-24)11-12-20(17

38(6):1260-5

24)25)26-18(21-12)22(2)16(23)11-13-6-8-14(9-7-13)15-5-3-4-10-20-15

InChiKey: VDOSWXIDETXFET-UHFFFAOYSA-N

Volasertib trihydrochloride - CAS# 946161-17-7 bradine Hydrochloride InChi: InChI=1S/C20H27NO3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21-24)11-12-20(17Volasertib (BI 6727) trihydrochloride is an orally active, highly potent and ATP competitive Polo like kinase 1 (PLK1) inhibitor with an IC50 of 0. 87 nM. Volasertib trihydrochloride inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. Volasertib trihydrochloride induces mitotic arrest and apoptosis. Volasertib trihydrochloride, a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models. Product information