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and phosphorylated Smad3 in keloid fibroblasts
CGS 21680A is the hydrochloride salt
Smiles: CC(C)N(C1=CC=C(F)C=C1F)C(=O)N1C=NN(C2=CC=C(Cl)C=C2Cl)C1=O
Smiles: BrC1=C2N=CC=NC2=CC=C1NC1NCCN=1
Dinaciclib - CAS# 779353-01-4 Catalog No.:M10712-10 and phosphorylated Smad3 in keloidDinaciclib, also known as SCH727965, is a potent CDK inhibitor with potential antineoplastic activity. Dinaciclib selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC(50) values of 1, 1, 3, and 4 nmol L, respectively. Compared with flavopiridol, Dinaciclib exhibits superior activity with an improved therapeutic index. Dinaciclib induced regression of established solid tumors in a range of mouse models