SB431542 - TGF-beta Inhibitor. CAS# 301836-41-9 60306 08 µM) and has shown

08 µM) and has shown dose-dependent tumor growth inhibition in a mouse MCF7 xenograft model alongside modulation of mTORC1 and mTORC2 biomarkers

and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors

InChi: InChI=1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24

The drug also inhibits the accumulation of all detectable ubiquitin at sites of DNA double-strand breaks (DSBs)

SB431542 - TGF-beta Inhibitor. CAS# 301836-41-9 60306 08 µM) and has shownSB 431542, CAS No. 301836 41 9, is a potent and selective inhibitor of TGF type I receptors ALK5 (IC50 ~94 nM), ALK4 (IC50 ~140 nM) and ALK7. It has no activities on the other ALK family members such as ALK2, ALK3 and ALK6, nor on components of the ERK, JNK, and p38 MAP kinase pathways. It specifically blocks Smad2 signaling, modulating gene expression related to EMT. In several publications SB 431542 has been used to enhance iPSC reprogramming,