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Smiles: COC1=CC=C(C=C1OC)C(=O)N1CCN(CC1)C1=CC2CCC(=O)NC=2C=C1
At 50 μM MD
Phillips J
PubMed PMID: 22295124
Trilaciclib 60012 Smiles: COC1=CC=C(C=C1OC)C(=O)N1CCN(CC1)C1=CC2CCC(=O)NC=2C=C1Trilaciclib (G1T28, G1T28 1) is a highly potent, selective and reversible cyclin dependent kinase 4 and 6 (CDK4 6) inhibitor. Trilaciclib inhibits CDK4 cyclin D1 and CDK6 cyclin D3 with IC50 of 1 nM and 4 nM, respectively. Product information CAS Number: 1374743 00 6 Molecular Weight: 446. 55 Formula: C24H30N8O Chemical Name: 2' ((5 (4 methylpiperazin 1 yl)pyridin 2 yl)amino) 7',8' dihydro 6'H spiro[cyclohexane 1,9' pyrazino[1',2': 1,5]pyrrolo[2,3
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