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Ku-0063794 also inhibited phosphorylation of the T-loop Thr308 residue of Akt phosphorylated by PDK1 (3-phosphoinositide-dependent protein kinase-1)
Nakahara T
InChi: InChI=1S/C23H35N5O2/c1-29-20-16-18-19(17-21(20)30-2)25-23(28-14-8-9-15-28)26-22(18)24-10-4-3-5-11-27-12-6-7-13-27/h16-17H
000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites
G-418 (disulfate) WS119 Ku-0063794 also inhibited phosphorylation ofGeneticin G418 is an aminoglycoside antibiotic, blocking polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells. Product information CAS Number: 108321 42 2 Molecular Weight: 594. 63 Formula: C20H42N4O14S Synonym: Geneticin sulfate Gentamicin sulfate Antibiotic G 418 sulfate Chemical Name: (2R,3S,4R,5R,6S) 5 amino 6 {[(1R,2S,3S,4R,6S) 4,6 diamino 3 {[(2R,3R,4R,5R) 3,5 dihydroxy 5 methyl 4 (methylamino)oxan 2
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