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W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM
In NCI-H345 cells possessing CCKB/gastrin receptors
18-pentahydroxy-7-[(4-hydroxyphenyl)methyl]-13-[(1H-indol-3-yl)methyl]-1
Smiles: CC(=O)N(CC)C1=CC(=CC=C1)C1=CC=NC2=C(C=NN12)C#N
Z-DQMD-FMK 17517 W146 is a selective antagonistInhibition of caspase 3 processing by Z DQMD FMK (Z Asp(OMe) Gln Met Asp(OMe) fluoromethylketone) did not restore cell number in the zinc deficient group, but resulted in processing of full length PKC to a 56 kDa fragment1. The inhibitory effect of specific caspase inhibitors (Z DQMD FMK, Z IETD FMK and Z LEHD FMK) suggests that the MG132 induced apoptotic cell death and depletion of GSH in SCLC cells are mediated by both activation of caspase 8 and
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