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PubMed Central PMCID: PMC3969090
70 and 200 nM for IKKβ
including HER2/ERBB2
Ladarixin inhibits human polymorphonuclear leukocyte (PMN) migration to CXCL8 (IC50 at 0
Brevetoxin-3 - CAS# 85079-48-7 333Acetyl lysyltyrosylcysteine amide PubMed Central PMCID: PMC3969090Brevetoxin 3 (PbTx 3) is a potent allosteric voltage gated Na+ channel activator and has multiple active centers (A ring lactone, C 42 of R side chain). Brevetoxin 3 (PbTx 3) has a high affinity to site 5 of the voltage sensitive Na+ channels, inhibits the inactivation of Na+ channels and prolongs the mean open time of these channels. Brevetoxin 3 (PbTx 3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation.
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