Bendamustine Hydrochloride ntan Hydrochloride Development of an Optimized Synthetic

Development of an Optimized Synthetic and Purification Process of S-2367 (Velneperit)

a potent ROCK inhibitor

2H2O/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21

InChiKey: UJKPHYRXOLRVJJ-AMPAVEGJSA-N

Bendamustine Hydrochloride ntan Hydrochloride Development of an Optimized SyntheticBendamustine is a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown, this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and