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is an inhibitor of MDMX that disrupts MDMX-p53 peptide interaction with an EC50 value of 4
The quality of the electron density for the methyl group of the methoxy moiety in GSK-3β inhibitor 2 does not allow its unambiguous placement in the model
(R)-Selisistat
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Cyclovirobuxine D - CAS# 860-79-7 Catalog No.:M12537-10 is an inhibitor of MDMXCyclovirobuxine D (CVB D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR. Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria mediated apoptosis. Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction.