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and caspase-like proteasomes
and MDA-MB436 ER negative breast cancer cells
Stefanutti C
2-hydroxyglutarate (2HG)
RKI-1447 - CAS# 1342278-01-6 Catalog No.:M60415-2S and caspase-like proteasomesRKI 1447, CAS No. 1342278 01 6, is a potent inhibitor of the Rho associated ROCK kinases with anti invasive and antitumor activities in breast cancer. RKI 1447 is a Type I kinase inhibitor that binds the ATP binding site through interactions with the hinge region and the DFG motif. RKI 1447 suppressed phosphorylation of the ROCK substrates MLC 2 and MYPT 1 in human cancer cells. Product information CAS Number: 1342278 01 6 Molecular Weight: 326. 37
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