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prevents epidermal growth factor receptoractivation and inhibits growth of cancer cells in a receptor number-dependent manner
24)17-10-11-27-18(17)19(22)26-2/h3-12
and is positively regulated by myc and strongly expressed in many tumors and tumor cell lines
PubMed Central PMCID: PMC5764324
GNE-617 - CAS# 1362154-70-8 60100 prevents epidermal growth factor receptoractivationGNE 617, CAS No. 1362154 70 8, is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with IC50 value of 5nM. Prolonged inhibition of nicotinamide phosphoribosyltransferase (NAMPT) is a strategy for targeting cancer metabolism. Product information CAS Number: 1362154 70 8 Molecular Weight: 427. 42 Formula: C21H15F2N3O3S Synonym: GNE 617 GNE 617 GNE617 Chemical Name: N (4 ((3,5 difluorophenyl)sulfonyl)benzyl)imidazo[1,2 a]pyridine 6