Selonsertib free base - CAS# 1448428-04-3 0321 InChi: InChI=1S/C26H28F3N7O2/c1-33-10-12-35(13-11-33)17-8-9-19(22(14-17)38-3)31-25-30-15-21-23(32-25)34(2)20-7-5-4-6-18(20)24(37)36(21)16-26(27

InChi: InChI=1S/C26H28F3N7O2/c1-33-10-12-35(13-11-33)17-8-9-19(22(14-17)38-3)31-25-30-15-21-23(32-25)34(2)20-7-5-4-6-18(20)24(37)36(21)16-26(27

It causes cell death through the apoptosis pathway

156(1):29-36

Pfeiffer (Y677G)

Selonsertib free base - CAS# 1448428-04-3 0321 InChi: InChI=1S/C26H28F3N7O2/c1-33-10-12-35(13-11-33)17-8-9-19(22(14-17)38-3)31-25-30-15-21-23(32-25)34(2)20-7-5-4-6-18(20)24(37)36(21)16-26(27Selonsertib free base, CAS No. 1448428 04 3, also known as GS 4997, is an orally bioavailable inhibitor of apoptosis signal regulating kinase 1 (ASK1), with potential anti inflammatory, antineoplastic and anti fibrotic activities. GS 4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP competitive manner, thereby preventing its phosphorylation and activation. GS 4997 prevents the production of inflammatory cytokines, down regulates