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Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase
IP administration of SR10067 was used at 30 mg/kg to mice
2018 Jan 2
Formula: C12H7Cl2NO3S2
VLX1570 - CAS# 1431280-51-1 288 Phosphorylation of 3'-azido-3'-deoxythymidine and selectiveVLX1570, CAS No. 1431280 51 1, is an inhibitor of the 19S proteasome specific deubiquitylating enzymes (DUBs) USP14 and UCHL5, with apoptosis inducing and antineoplastic activities. Upon administration, VLX1570 specifically binds to both USP14 and UCHL5, thereby blocking their deubiquitylating activity. This blocks the ubiquitin proteasome degradation pathway, prevents the degradation of defective proteins, and leads to an accumulation of poly
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