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TTP488 HCl
[Epub ahead of print] PubMed PMID: 30571144
All LGK974-sensitive pancreatic cancer cell lines carried inactivating mutations of RNF43
31(6):671-8
PF-06826647 Size:100mg solid TTP488 HClPF 06826647 (Tyk2 IN 8, compound 10) is a selective and orally administered inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 17 nM for binding to TYK2 catalytically active JH1 domain. PF 06826647 (Tyk2 IN 8, compound 10) also inhibits JAK1 and JAK2 with IC50 of 383 nM and 74 nM, respectively. PF 06826647 (Tyk2 IN 8, compound 10) is used in the treatment of psoriasis (PSO). Product information CAS Number: 2127109 84 4 Molecular Weight: 383. 41
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