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HDAC inhibitor 4SC-202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones
is a n orally bioavailable small molecule with potential antiangiogenic and antineoplastic activities
and the effect is time and dose dependent
InChiKey: YEZCRNKNZWDABB-PZBWUIGESA-N
SAR405838 atel HDAC inhibitor 4SC-202 selectively bindsSAR405838 is a highly potent and selective MDM2 inhibitor, binds to MDM2 with Ki= 0. 88 nM and has high specificity over other proteins. IC50 value: 0. 88 nM (Ki) [1] Target: MDM2 in vitro: SAR405838 potently inhibits cell growth in cancer cell lines, including SJSA 1 (IC50, 0. 092 M), RS4; 11 (IC50, 0. 089 M), LNCaP (IC50, 0. 27 M), and HCT 116 (IC50, 0. 20 M) cells, and displays high selectivity over cancer cell lines with mutated or deleted p53,
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