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Van Glabbeke M
3-dimethylphenyl)-1H-pyrazolo[3
and the active metabolite of LX1606 (Telotristat etiprate)
13-tetraoxa-1-azapentadecan-1-yl)-2-(2
Setipiprant 8129 Van Glabbeke MSetipiprant is an orally available, selective CRTH2 antagonist. CRTH2 is a G protein coupled receptor for PGD2. IC50 value: 6. 0 nMTarget: PGD2in vitro: Setipiprant is an orally available, selective CRTH2 (chemoattractant receptor homologous molecule expressed on T helper [Th] 2 cells) antagonist. CRTH2 is a G protein coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases,
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