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31(31):7152-4
Int J Clin Exp Pathol
7a-hexahydro-1
CAS Number: 1031063-36-1
Nexturastat A utidine 31(31):7152-4Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC50= 5. 02 + 0. 60 nM). Nexturastat A possesses antiproliferative effects against melanoma cells. Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation. Dysregulation of histone acetylation can lead to the development of cancers. There is renewed interest in capitalizing
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