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12 hours) shows near complete AR degradation (>98%) in prostate cancer cells
4-d]pyrimidin-6-amine
Med Lett Drugs Ther
VLX1570 suppresses the viability of BCWM
LY3009120 Catalog No.:M8369-2 12 hours) shows near completeLY3009120, also known as DP 4978, is potent and selective pan RAF inhibitor with potential anticancer activity. LY3009120 showed activities against BRaf or Ras mutant tumor cells . LY3009120 binds to ARaf, BRaf and CRaf isoforms with similar affinity in cells with activating mutations of BRaf or KRas. LY3009120 induces minimal paradoxical pathway activation in NRas or KRas mutant cells. LY3009120 inhibits MEK phosphorylation and cell proliferation in