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Pulm Pharmacol Ther
PubMed PMID: 21368229
CYC116 is an orally bioavailable small molecule multi-kinase inhibitor with antineoplastic activity
InChi: InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6
Gliotoxin Size:10mg solid Pulm Pharmacol TherGliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells. Gliotoxin inhibits inducible NF B activity by preventing IB degradation, which consequently induces host cell apoptosis. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus
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