Quinolinic acid ycycline monohydrate SJM-3 binds at the high-affinity

SJM-3 binds at the high-affinity benzodiazepine binding site at theα+/γ- subunit interface but effects its action through another site presumably located within the transmembrane domain

Treatment with Danusertib results in an increase in p53 protein levels and an associated increase in p21 protein

in primary human xenograft studies

It inhibits HDAC1 and HDAC3 with IC50 of 0

Quinolinic acid ycycline monohydrate SJM-3 binds at the high-affinityQuinolinic acid is an endogenous N methyl D aspartate (NMDA) receptor agonist synthesized from L tryptophan via the kynurenine pathway and thereby has the potential of mediating N methyl D aspartate neuronal damage and dysfunction. Product information CAS Number: 89 00 9 Molecular Weight: 167. 12 Formula: C7H5NO4 Chemical Name: pyridine 2,3 dicarboxylic acid Smiles: OC(=O)C1=CC=CN=C1C(O)=O InChiKey: GJAWHXHKYYXBSV UHFFFAOYSA N InChi: InChI=1S C7H5NO4