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The binding affinity of SJM-3 at wild type receptors is determined by displacement of [3H]-Flunitrazepam and [3H]-Ro15-1788 and indicates a Ki of SJM-3 amounting to 218±70 nM and 242±38 nM
COC1=CC2CCNC(CC3=CC(OC)=C(C=C3)OC)C=2C=C1OC
CAS Number: 1356962-20-3
NF-κB activation is inhibited by 50 μM Oxaprozin
PTP Inhibitor IV - CAS# 329317-98-8 Catalog No.:M23057-C The binding affinity of SJM-3IC50: 1. 8, 2. 5, 8. 4, 13, 20, 6. 4, and 6. 7 M for SHP 2, PTP1B, PTP , PTP Meg 2, PTP , PTP , and PTP , respectively PTP Inhibitor IV is a protein tyrosine phosphatases (PTPs) inhibitor. PTPs are reported to be important in the regulation of various signal transduction processes. Enzymes of this class are considered as potential therapeutic targets in the treatment of various diseases including inflammation, diabetes, as well as cancer. However,
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