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It upregulates frataxin mRNA and protein levels dose-dependently in cultures of unstimulated peripheral blood mononuclear cells (PBMC) obtained from FRDA patients
GNF-2 increased the effects of AKIs on unmutated BCR/ABL
916232-21-8
35-25-/t30-
A01 - Smurf1 E3 Ubiquitin Ligase Inhibitor. CAS# 1007647-73-5 Catalog No.:M60249-10S It upregulates frataxin mRNA andA01, CAS No. 1007647 73 5, is a potent and selective Smurf1 E3 ubiquitin ligase inhibitor with Kd ~3. 7 nM. It attenuates Smurf1 mediated Smad 1 5 degradation and enhances BMP signaling. It also potentiates BMP 2 induced osteoblastic activity in C2C12 myoblasts and MC3T3 E1 osteoblast precursor cells. Product information CAS Number: 1007647 73 5 Molecular Weight: 512. 93 Formula: C22H20ClF3N4O3S Chemical Name: (4 ((4 chloro 3
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