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2013 Nov 21
InChiKey: KRIKILRRJCIWNB-UHFFFAOYSA-N
3-dihydro-1H-benzo[d]imidazol-5-yl)benzenesulfonamide
086 microM) and the closely related InsR (IC50 = 2
TAK-733 0162 2013 Nov 21TAK 733 is an orally bioavailable small molecule inhibitor of MEK1 and MEK2 (MEK1 2) with potential antineoplastic activity. MEK inhibitor TAK 733 selectively binds to and inhibits the activity of MEK1 2, preventing the activation of MEK1 2 dependent effector proteins and transcription factors, which may result in the inhibition of growth factor mediated cell signaling and tumor cell proliferation. MEK1 2 (MAP2K1 K2) are dual specificity threonine
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