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21(9):1513-23
Monocarboxylate transporters (MCTs) catalyze the proton-linked transport of monocarboxylates such as L-lactate
The subcutaneous tumor growth of both T24 and HeLa cell xenografts treated with PAI-039 is markedly reduced compared with untreated controls
InChiKey: PSZANHDEEIPWLX-UHFFFAOYSA-N
2-Methoxyestradiol Size:10mg solid 21(9):1513-232 methoxyestradiol, also known as 2 ME, is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2 Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation,
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