Pay in 4 interest-free payments of $6.25 Learn more
Ships within 48 hours · Estimated delivery Aug 8 - Aug 13
It disrupts microtubules by binding to β−tubulin and preventing formation of one of the two interchain disulfide linkages
with an IC50 of 100 μM for S3I-201
InChi: InChI=1S/C17H18N2O4/c20-11-10-19(15-4-2-1-3-5-15)16(21)12-13-6-8-14(9-7-13)17(22)18-23/h1-9
(2002) J Biol Chem
Harmine - DYRK1A Inhibitor. CAS# 442-51-3 size:10 mg solid It disrupts microtubules by bindingHarmine, CAS No. 442 51 3, is a potent, selective and orally bioavailable DYRK1A inhibitor with IC50 of 80 nM. It inhibits phosphorylation of tau directly by DYRK1A (IC50 ~700 nM). It has >10 fold selectivity over DYRK3 and DYRK2 (IC50 ~800 nM and 900 nM respectively. Harmine is also a unique regulator of PPAR expression that acts by inhibiting the Wnt signalling pathway in a cell specific manner. It attenuates inflammatory gene expression (TNF, IL 1,
US$ 899.50
US$ 1312.00
US$ 120.00
US$ 100.00
US$ 100.00
US$ 100.00
US$ 100.00
US$ 1592.00