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Bromosporine - Pan-bromodomain Inhibitor. CAS# 1619994-69-2 istone Demethylase Epub 2012 Jun 1

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Description

Epub 2012 Jun 1

28(5):557-68

957054-33-0 (mesylate)

Molecular Weight: 442

Bromosporine - Pan-bromodomain Inhibitor. CAS# 1619994-69-2 istone Demethylase Epub 2012 Jun 1Bromosporine, CAS No. 1619994 69 2, is a broad spectrum inhibitor for bromodomains with IC50 of 0. 41 M, 0. 29 M, 0. 122 M and 0. 017 M for BRD2, BRD4, BRD9 and CECR2, respectively. In cell based assays, Bromosporine (1 M) accelerates FRAP recovery of BRD4 and CREBBP, while shows no activities against TIF1, BAZ2A, and SMARCA2 (at 10 M). Bromosporine shows moderate cytotoxicity in HeLa cells at 18 M. It is a very useful chemical probe for bromodomain

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