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M3258 Size:Contact [email protected] for quotation 6-dimethoxy-2

SKU: 46333822115

4.0
USD100.00 USD137.00

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Description

6-dimethoxy-2

343(2):239-48

Docetaxel displays potent and broad antineoplastic properties

1998 Apr 3

M3258 Size:Contact [email protected] for quotation 6-dimethoxy-2M3258 is an orally bioavailable, potent, reversible and highly selective immunoproteasome subunit LMP7 (5i) inhibitor. M3258 exerts high biochemical (IC50=3. 6 nM) and cellular (IC50=3. 4 nM) potency against the LMP7 subunit. M3258 shows strong antitumor efficacy in multiple myeloma xenograft models. M3258 leads to a significant and prolonged suppression of tumor LMP7 activity and ubiquitinated protein turnover and the induction of apoptosis in

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