Pay in 4 interest-free payments of $25.00 Learn more
Ships within 48 hours · Estimated delivery Aug 1 - Aug 6
C2H4O2/c15-14(16)18-17-9-3-5-11-6-4-10-19(11)12-7-1-2-8-13(12)20(21)22
with IC50 values of 79 μM and 2
Solubility: DMSO : 100 mg/mL (173
also called DAPK3)
COTI-2 nositol C2H4O2/c15-14(16)18-17-9-3-5-11-6-4-10-19(11)12-7-1-2-8-13(12)20(21)22COTI 2, an anti cancer drug with low toxicity, is an orally available third generation activator of p53 mutant forms. COTI 2 acts both by reactivating mutant p53 and inhibiting the PI3K AKT mTOR pathway. COTI 2 induces apoptosis in multiple human tumor cell lines. COTI 2 exhibits antitumor activity in HNSCC through p53 dependent and independent mechanisms. COTI 2 converts mutant p53 to wild type conformation. Product information CAS Number: 1039455 84