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Discovery of I-BRD9
TAK-875 was used at 1 µM final concentration in various in vitro assays
and Ret with IC50 of 3 nM
Hsc70 and Grp7
GNF7156, β Cell Proliferation Inducer - CAS# 2041071-54-7 la-Ala-Asn-PAB-PNP Discovery of I-BRD9GNF7156, CAS No. 2041071 54 7, is a highly potent and selective small molecule that promotes pancreatic cell proliferation in rodent EC50 ~2. 2 Mand human primary islets (EC50 ~0. 76 M). It acts most likely as a result of combined inhibition of DYRK1A and GSK3B. GNF7156 treated human islets retain functionality in vitro and after transplantation into diabetic mice. Oral dosing of GNF7156 in diabetic mice induces cell proliferation, increases cell mass
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