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JSH-23 - CAS# 749886-87-1 Catalog No.:M9452-10 Chemical Name: 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1

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Description

Chemical Name: 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1

Pre-incubation of platelets with VX-702 (1 μM) completely or partially inhibits p38 activation (IC50 4 to 20 nM) induced by platelet agonists including thrombin

8-tetramethyl-2-[(4R

a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor from the roots of Angelica dahurica

JSH-23 - CAS# 749886-87-1 Catalog No.:M9452-10 Chemical Name: 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1JSH 23 is a nuclear factor kappa B (NF B) nuclear translocation inhibitor. JSH 23 inhibits LPS and cytokine induced nuclear translocation of the p65 subunit of NF kB as analyzed by EMSA and western blot. JSH 23 treatment significantly reversed the nerve conduction and nerve blood flow deficits seen in diabetic animals. Reduction in mechanical pain threshold was also partially corrected by the treatment. Protein expression studies showed that nuclear

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